Preparation,Characterization and Study of Biological Activity for some new derivatives Mannich's bases derived from Shiff's bases
This paper involves synthesis new Mannich bases derived from Shiff' bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to pr...
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Veröffentlicht in: | Research journal of pharmacy and technology 2021-11, Vol.14 (11), p.6025-6032 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | This paper involves synthesis new Mannich bases derived from Shiff' bases which prepared from isatin by the reaction of isatin with different aromatic amines to prepare Shiff bases derivatives (M, G, B, R, X, S), then Shiff's bases derivatives reacted with formaldehyde and piperazine to produce Mannich bases derivatives (M1, G1, B1, R1, X1, S1). The third step included the assay of biological activity of all compounds against four types of pathogens bacteria (Staphylococcus aureus, Granutice tella adiacens) gram positive and (E. coli, Proteus mirabilis) gram negative the results exhibited excellent biological activity for all derivatives compared to antibiotics (Ampicillin and Ciprofloxacin) these structures were identified by FT-IR,1HNMRand 13CNMR. |
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ISSN: | 0974-3618 0974-360X 0974-306X |
DOI: | 10.52711/0974-360X.2021.01047 |