Development of Methods for Determination of the Ag, Cu, Fe, and Zn Contents in Materials Based on Calcium Phosphate for Medical Purposes

Using inductively coupled plasma atomic emission spectrometry (ICP-AES) and atomic absorption spectroscopy (AAS), we developed methods that allow express determination of impurity elements (Ag, Cu, Fe, and Zn) with good metrological characteristics in a wide range of concentrations from 0.0005 to 10% in medical materials based on calcium phosphate, without preliminary separation of the matrix and without the use of standard composition samples. The relative standard deviation ( S r ) is 0.05–0.005 for the element contents from 1 to 10% and does not exceed 0.15 for the element contents from 0.0005 to 0.1%. New methods of analytical control provided research on the development of composite materials based on substituted calcium phosphate for medical purposes which exhibit antibacterial activity.