Novel Validated Method for the Estimation of Capecitabine in Pharmaceutical Dosage forms by First Order Derivative Spectrophotometry

An easy, fast, precise and cost effective First derivative UV estimation method has been investigated for the estimation of Capecitabine in various pharmaceutical dosage forms. The novel method was developed using Shimadzu Spectronic 1800 model UV-Visible Spectrophotometer. The region on the UV-spec...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Research journal of pharmacy and technology 2021-10, Vol.14 (10), p.5238-5241
Hauptverfasser: Karajgi, S. R, M, Somashekhar, Chincholi, Pooja, Deginal, Laxmi S., Bhouramma, Mhetre, Mirji, Prabhavati, Kulkarni, R.V
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An easy, fast, precise and cost effective First derivative UV estimation method has been investigated for the estimation of Capecitabine in various pharmaceutical dosage forms. The novel method was developed using Shimadzu Spectronic 1800 model UV-Visible Spectrophotometer. The region on the UV-spectrum between 240nm to 400nm in distilled water as the solvent was found to be suitable for the first derivative peak measurement of Capecitabine with a Linearity range throughout the concentrations of 40 microgram/ml to 80 microgram/ml. The method was successfully employed for the routine estimation on tablet dosage forms. The method was validated according to ICH guidelines. No interference from additives was observed.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.52711/0974-360X.2021.00912