Novel Validated Method for the Estimation of Capecitabine in Pharmaceutical Dosage forms by First Order Derivative Spectrophotometry
An easy, fast, precise and cost effective First derivative UV estimation method has been investigated for the estimation of Capecitabine in various pharmaceutical dosage forms. The novel method was developed using Shimadzu Spectronic 1800 model UV-Visible Spectrophotometer. The region on the UV-spec...
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Veröffentlicht in: | Research journal of pharmacy and technology 2021-10, Vol.14 (10), p.5238-5241 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | An easy, fast, precise and cost effective First derivative UV estimation method has been investigated for the estimation of Capecitabine in various pharmaceutical dosage forms. The novel method was developed using Shimadzu Spectronic 1800 model UV-Visible Spectrophotometer. The region on the UV-spectrum between 240nm to 400nm in distilled water as the solvent was found to be suitable for the first derivative peak measurement of Capecitabine with a Linearity range throughout the concentrations of 40 microgram/ml to 80 microgram/ml. The method was successfully employed for the routine estimation on tablet dosage forms. The method was validated according to ICH guidelines. No interference from additives was observed. |
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ISSN: | 0974-3618 0974-360X 0974-306X |
DOI: | 10.52711/0974-360X.2021.00912 |