Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice
The main aim of the study was to evaluate the chemopreventive potential of Kayan Karpam (KK) against Benzo(a) Pyrene (B(a)P) induced lung carcinogenesis in experimental mice. In this study, we evaluated the impact of KK as an effective antioxidant and anticarcinogenic agent against B(a)P, a possible...
Gespeichert in:
| Veröffentlicht in: | Research journal of pharmacy and technology 2021-09, Vol.14 (9), p.4640-4646 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4646 |
|---|---|
| container_issue | 9 |
| container_start_page | 4640 |
| container_title | Research journal of pharmacy and technology |
| container_volume | 14 |
| creator | Munireddy, Durga Devi Venkatachalam, Karthikkumar Thangavelu, Kalaichelvan Pudhupalayam |
| description | The main aim of the study was to evaluate the chemopreventive potential of Kayan Karpam (KK) against Benzo(a) Pyrene (B(a)P) induced lung carcinogenesis in experimental mice. In this study, we evaluated the impact of KK as an effective antioxidant and anticarcinogenic agent against B(a)P, a possible carcinogen present in cigarette smoke. All mice were randomly assorted into five groups. Group I mice served as control (Control), group II mice were received KK at the dosage of 250mg/kg b.wt. for 16 weeks. Groups III-VI received B(a)P at the dosage of 50mg/kg b.wt. weekly twice orally for the first 4 weeks. Further, along with B(a)P, group IV received KK, as like group 2 for 16 weeks, group V mice received B(a)P, as like groups 3 and 4, along with KK starting from the 9th week of the experimental period. We observed, that carcinogen induced mice treated with different treatment regimens of KK showed a potent chemopreventive action. Significant (P |
| doi_str_mv | 10.52711/0974-360X.2021.00806 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2671370372</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2671370372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c144t-c03ebb3444495c4e2e6b73d816d6e941bc54afb9a54698ba983000a73abfddd43</originalsourceid><addsrcrecordid>eNo9kN1LwzAQwIMoOHR_ghDwZXvoTJo0bR_n8AsH-jDBt5AmV-1ok5q2w_33ppvsHu77jrsfQjeULJI4pfSO5CmPmCCfi5jEdEFIRsQZmpzS5yefZpdo2nVbEkRkScyzCRpW39C41sMObF_tALeuHz1VY1fiV7VXNmjfqgbPNl6Zqq-cDcXS-Wao1RjNsbP4fracv-PKmkGDwfVgv7BWVoMPOQy_LfiqCXvDZFNpuEYXpao7mP7bK_Tx-LBZPUfrt6eX1XIdacp5H2nCoCgYD5InmkMMokiZyagwAnJOC51wVRa5SrjIs0LlGQuvqZSpojTGcHaFbo97W-9-Buh6uXWDD_d3MhYpZSlhaRy6kmOX9q7rPJSyDdcqv5eUyANkORKUI005QpYHyOwPMjJwQg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2671370372</pqid></control><display><type>article</type><title>Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Munireddy, Durga Devi ; Venkatachalam, Karthikkumar ; Thangavelu, Kalaichelvan Pudhupalayam</creator><creatorcontrib>Munireddy, Durga Devi ; Venkatachalam, Karthikkumar ; Thangavelu, Kalaichelvan Pudhupalayam</creatorcontrib><description>The main aim of the study was to evaluate the chemopreventive potential of Kayan Karpam (KK) against Benzo(a) Pyrene (B(a)P) induced lung carcinogenesis in experimental mice. In this study, we evaluated the impact of KK as an effective antioxidant and anticarcinogenic agent against B(a)P, a possible carcinogen present in cigarette smoke. All mice were randomly assorted into five groups. Group I mice served as control (Control), group II mice were received KK at the dosage of 250mg/kg b.wt. for 16 weeks. Groups III-VI received B(a)P at the dosage of 50mg/kg b.wt. weekly twice orally for the first 4 weeks. Further, along with B(a)P, group IV received KK, as like group 2 for 16 weeks, group V mice received B(a)P, as like groups 3 and 4, along with KK starting from the 9th week of the experimental period. We observed, that carcinogen induced mice treated with different treatment regimens of KK showed a potent chemopreventive action. Significant (P<0.05) increases in cellular enzymatic antioxidants such as SOD, CAT and GPx and levels of non-enzymatic antioxidants like GSH, vitamins E and C were noted in KK treated mice. Highly significant reductions were observed in the levels of lipid peroxidative by products and lung cancer marker enzymes like AHH, ᵧ-GT, 5’-ND and LDH in the mice administered with KK. Supplementation with KK to tumor bearing mice normalized the expression patterns of pro- and anti- apoptotic proteins (p21, Bax, Bcl-2), modulated NF-κB, and reduced the levels of COX-2. These findings further suggest the view that the Indian medicinal plants present in KK are promising sources of potential drugs against lung cancer.</description><identifier>ISSN: 0974-3618</identifier><identifier>EISSN: 0974-360X</identifier><identifier>EISSN: 0974-306X</identifier><identifier>DOI: 10.52711/0974-360X.2021.00806</identifier><language>eng</language><publisher>Raipur: A&V Publications</publisher><subject>Animals ; Antibodies ; Antioxidants ; Carcinogens ; Drug dosages ; Herbal medicine ; Lung cancer ; Proteins</subject><ispartof>Research journal of pharmacy and technology, 2021-09, Vol.14 (9), p.4640-4646</ispartof><rights>Copyright A&V Publications Sep 2021</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c144t-c03ebb3444495c4e2e6b73d816d6e941bc54afb9a54698ba983000a73abfddd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Munireddy, Durga Devi</creatorcontrib><creatorcontrib>Venkatachalam, Karthikkumar</creatorcontrib><creatorcontrib>Thangavelu, Kalaichelvan Pudhupalayam</creatorcontrib><title>Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice</title><title>Research journal of pharmacy and technology</title><description>The main aim of the study was to evaluate the chemopreventive potential of Kayan Karpam (KK) against Benzo(a) Pyrene (B(a)P) induced lung carcinogenesis in experimental mice. In this study, we evaluated the impact of KK as an effective antioxidant and anticarcinogenic agent against B(a)P, a possible carcinogen present in cigarette smoke. All mice were randomly assorted into five groups. Group I mice served as control (Control), group II mice were received KK at the dosage of 250mg/kg b.wt. for 16 weeks. Groups III-VI received B(a)P at the dosage of 50mg/kg b.wt. weekly twice orally for the first 4 weeks. Further, along with B(a)P, group IV received KK, as like group 2 for 16 weeks, group V mice received B(a)P, as like groups 3 and 4, along with KK starting from the 9th week of the experimental period. We observed, that carcinogen induced mice treated with different treatment regimens of KK showed a potent chemopreventive action. Significant (P<0.05) increases in cellular enzymatic antioxidants such as SOD, CAT and GPx and levels of non-enzymatic antioxidants like GSH, vitamins E and C were noted in KK treated mice. Highly significant reductions were observed in the levels of lipid peroxidative by products and lung cancer marker enzymes like AHH, ᵧ-GT, 5’-ND and LDH in the mice administered with KK. Supplementation with KK to tumor bearing mice normalized the expression patterns of pro- and anti- apoptotic proteins (p21, Bax, Bcl-2), modulated NF-κB, and reduced the levels of COX-2. These findings further suggest the view that the Indian medicinal plants present in KK are promising sources of potential drugs against lung cancer.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antioxidants</subject><subject>Carcinogens</subject><subject>Drug dosages</subject><subject>Herbal medicine</subject><subject>Lung cancer</subject><subject>Proteins</subject><issn>0974-3618</issn><issn>0974-360X</issn><issn>0974-306X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNo9kN1LwzAQwIMoOHR_ghDwZXvoTJo0bR_n8AsH-jDBt5AmV-1ok5q2w_33ppvsHu77jrsfQjeULJI4pfSO5CmPmCCfi5jEdEFIRsQZmpzS5yefZpdo2nVbEkRkScyzCRpW39C41sMObF_tALeuHz1VY1fiV7VXNmjfqgbPNl6Zqq-cDcXS-Wao1RjNsbP4fracv-PKmkGDwfVgv7BWVoMPOQy_LfiqCXvDZFNpuEYXpao7mP7bK_Tx-LBZPUfrt6eX1XIdacp5H2nCoCgYD5InmkMMokiZyagwAnJOC51wVRa5SrjIs0LlGQuvqZSpojTGcHaFbo97W-9-Buh6uXWDD_d3MhYpZSlhaRy6kmOX9q7rPJSyDdcqv5eUyANkORKUI005QpYHyOwPMjJwQg</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Munireddy, Durga Devi</creator><creator>Venkatachalam, Karthikkumar</creator><creator>Thangavelu, Kalaichelvan Pudhupalayam</creator><general>A&V Publications</general><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04S</scope><scope>04W</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20210901</creationdate><title>Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice</title><author>Munireddy, Durga Devi ; Venkatachalam, Karthikkumar ; Thangavelu, Kalaichelvan Pudhupalayam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c144t-c03ebb3444495c4e2e6b73d816d6e941bc54afb9a54698ba983000a73abfddd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antioxidants</topic><topic>Carcinogens</topic><topic>Drug dosages</topic><topic>Herbal medicine</topic><topic>Lung cancer</topic><topic>Proteins</topic><toplevel>online_resources</toplevel><creatorcontrib>Munireddy, Durga Devi</creatorcontrib><creatorcontrib>Venkatachalam, Karthikkumar</creatorcontrib><creatorcontrib>Thangavelu, Kalaichelvan Pudhupalayam</creatorcontrib><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Business</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Research journal of pharmacy and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Munireddy, Durga Devi</au><au>Venkatachalam, Karthikkumar</au><au>Thangavelu, Kalaichelvan Pudhupalayam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice</atitle><jtitle>Research journal of pharmacy and technology</jtitle><date>2021-09-01</date><risdate>2021</risdate><volume>14</volume><issue>9</issue><spage>4640</spage><epage>4646</epage><pages>4640-4646</pages><issn>0974-3618</issn><eissn>0974-360X</eissn><eissn>0974-306X</eissn><abstract>The main aim of the study was to evaluate the chemopreventive potential of Kayan Karpam (KK) against Benzo(a) Pyrene (B(a)P) induced lung carcinogenesis in experimental mice. In this study, we evaluated the impact of KK as an effective antioxidant and anticarcinogenic agent against B(a)P, a possible carcinogen present in cigarette smoke. All mice were randomly assorted into five groups. Group I mice served as control (Control), group II mice were received KK at the dosage of 250mg/kg b.wt. for 16 weeks. Groups III-VI received B(a)P at the dosage of 50mg/kg b.wt. weekly twice orally for the first 4 weeks. Further, along with B(a)P, group IV received KK, as like group 2 for 16 weeks, group V mice received B(a)P, as like groups 3 and 4, along with KK starting from the 9th week of the experimental period. We observed, that carcinogen induced mice treated with different treatment regimens of KK showed a potent chemopreventive action. Significant (P<0.05) increases in cellular enzymatic antioxidants such as SOD, CAT and GPx and levels of non-enzymatic antioxidants like GSH, vitamins E and C were noted in KK treated mice. Highly significant reductions were observed in the levels of lipid peroxidative by products and lung cancer marker enzymes like AHH, ᵧ-GT, 5’-ND and LDH in the mice administered with KK. Supplementation with KK to tumor bearing mice normalized the expression patterns of pro- and anti- apoptotic proteins (p21, Bax, Bcl-2), modulated NF-κB, and reduced the levels of COX-2. These findings further suggest the view that the Indian medicinal plants present in KK are promising sources of potential drugs against lung cancer.</abstract><cop>Raipur</cop><pub>A&V Publications</pub><doi>10.52711/0974-360X.2021.00806</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0974-3618 |
| ispartof | Research journal of pharmacy and technology, 2021-09, Vol.14 (9), p.4640-4646 |
| issn | 0974-3618 0974-360X 0974-306X |
| language | eng |
| recordid | cdi_proquest_journals_2671370372 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Antibodies Antioxidants Carcinogens Drug dosages Herbal medicine Lung cancer Proteins |
| title | Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T20%3A09%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chemopreventive%20potential%20of%20Kayan%20Karpam%20(Traditional%20formulation)%20on%20B(A)P%20induced%20lung%20cancer%20in%20experimental%20mice&rft.jtitle=Research%20journal%20of%20pharmacy%20and%20technology&rft.au=Munireddy,%20Durga%20Devi&rft.date=2021-09-01&rft.volume=14&rft.issue=9&rft.spage=4640&rft.epage=4646&rft.pages=4640-4646&rft.issn=0974-3618&rft.eissn=0974-360X&rft_id=info:doi/10.52711/0974-360X.2021.00806&rft_dat=%3Cproquest_cross%3E2671370372%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2671370372&rft_id=info:pmid/&rfr_iscdi=true |