Chemopreventive potential of Kayan Karpam (Traditional formulation) on B(A)P induced lung cancer in experimental mice

The main aim of the study was to evaluate the chemopreventive potential of Kayan Karpam (KK) against Benzo(a) Pyrene (B(a)P) induced lung carcinogenesis in experimental mice. In this study, we evaluated the impact of KK as an effective antioxidant and anticarcinogenic agent against B(a)P, a possible carcinogen present in cigarette smoke. All mice were randomly assorted into five groups. Group I mice served as control (Control), group II mice were received KK at the dosage of 250mg/kg b.wt. for 16 weeks. Groups III-VI received B(a)P at the dosage of 50mg/kg b.wt. weekly twice orally for the first 4 weeks. Further, along with B(a)P, group IV received KK, as like group 2 for 16 weeks, group V mice received B(a)P, as like groups 3 and 4, along with KK starting from the 9th week of the experimental period. We observed, that carcinogen induced mice treated with different treatment regimens of KK showed a potent chemopreventive action. Significant (P