Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Tranexamic acid is an antifibrinolytic drug that reduces bleeding in patients undergoing cesarean section or cardiac surgery. In this randomized trial involving patients undergoing noncardiac surgery, the risk of bleeding was lower with tranexamic acid than with placebo, but noninferiority with resp...

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Veröffentlicht in:	The New England journal of medicine 2022-05, Vol.386 (21), p.1986-1997
Hauptverfasser:	Devereaux, P.J., Marcucci, Maura, Painter, Thomas W., Conen, David, Lomivorotov, Vladimir, Sessler, Daniel I., Chan, Matthew T.V., Borges, Flavia K., Martínez-Zapata, María J., Wang, Chew Yin, Xavier, Denis, Ofori, Sandra N., Wang, Michael K., Efremov, Sergey, Landoni, Giovanni, Kleinlugtenbelt, Ydo V., Szczeklik, Wojciech, Schmartz, Denis, Garg, Amit X., Short, Timothy G., Wittmann, Maria, Meyhoff, Christian S., Amir, Mohammed, Torres, David, Patel, Ameen, Duceppe, Emmanuelle, Ruetzler, Kurt, Parlow, Joel L., Tandon, Vikas, Fleischmann, Edith, Polanczyk, Carisi A., Lamy, Andre, Astrakov, Sergey V., Rao, Mangala, Wu, William K.K., Bhatt, Keyur, de Nadal, Miriam, Likhvantsev, Valery V., Paniagua, Pilar, Aguado, Hector J., Whitlock, Richard P., McGillion, Michael H., Prystajecky, Michael, Vincent, Jessica, Eikelboom, John, Copland, Ingrid, Balasubramanian, Kumar, Turan, Alparslan, Bangdiwala, Shrikant I., Stillo, David, Gross, Peter L., Cafaro, Teresa, Alfonsi, Pascal, Roshanov, Pavel S., Belley-Côté, Emilie P., Spence, Jessica, Richards, Toby, VanHelder, Tomas, McIntyre, William, Guyatt, Gordon, Yusuf, Salim, Leslie, Kate
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Anticoagulation Antifibrinolytic agents Antifibrinolytic Agents - adverse effects Antifibrinolytic Agents - therapeutic use Bleeding Canada Cardiology Clinical Medicine Clinical Medicine General Coagulation Confidence intervals Coronaviruses COVID-19 Creatinine Design Heart attacks Heart surgery Hematology Hemorrhage - etiology Hemorrhage - prevention & control Hospital-Based Clinical Medicine Humans Hypertension Hypotension Intravenous administration Medical research Oncology Patients Placebos Recruitment Statistical analysis Surgery Surgery General Surgical Procedures, Operative Thromboembolism Thrombosis Thrombosis - chemically induced Thrombosis - drug therapy Tranexamic Acid - adverse effects Tranexamic Acid - therapeutic use
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Zusammenfassung:	Tranexamic acid is an antifibrinolytic drug that reduces bleeding in patients undergoing cesarean section or cardiac surgery. In this randomized trial involving patients undergoing noncardiac surgery, the risk of bleeding was lower with tranexamic acid than with placebo, but noninferiority with respect to cardiovascular complications was not established.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2201171