Treatment of Painful Lower Extremity Neuromas with Processed Nerve Allograft

Background: Painful neuromas remain a challenge for both patients and surgeons. Despite numerous described treatments, they are often unreliable with variable outcomes. This study evaluated the use ofprocessed nerve allografts for the treatment of painful lower extremity neuromas by either reconstruction or transposition into muscle. The null hypothesis was that both techniques for painful neuromas would not result in improved pain or functional outcomes. Methods: Retrospective review was performed of 12 patients treated by a single surgeon for painful lower extremity neuromas with the utilization of processed nerve allograft either with elongation of the residual nerve stump and translocation into muscle (n = 7) or nerve reconstruction (n=5). Patient demographics, surgical details, and outcomes data were evaluated comparing preoperative and postoperative PROMTS (Patient Reported Outcomes Measurement Information System) scores. Patients underwent preoperative workup with imaging (ultrasound and magnetic resonance imaging). Utilizing a processed nerve allograft, reconstruction was performed if the proximal and distal nerve ends were identifiable, otherwise translocation to muscle was performed to preserve proximal nerve branches. Results: Average follow-up was 15.2 months (SD: 11.4). Neuroma locations included intermetatarsal (n = 4), sural (n = 1), deep peroneal (n = 3), superficial peroneal (n = 4), and medial plantar (n = 1). Five patients failed a previous neuroma surgery, five patients had prior surgery in the zone of injury, one patient sustained a traumatic laceration, and one patient had a motor vehicle collision (MVC) requiring multiple previous surgeries. All but one patient had at least one prior surgery, with seven patients (five translocation, two reconstruction) having undergone a previous attempt to specifically address neuroma pain. Preoperative injection when administered demonstrated improvement in pain and symptoms in six of seven and two of two of the translocation and reconstruction groups, respectively. Preoperative ultrasound identified a neuroma in four of seven translocation and all four reconstruction patients. Pathology confirmed a neuroma in all 12 patients. Outcome data were available for 10 patients (six translocation, four reconstruction), which demonstrated a statistically significant improvement in PROMTS interference (p = 0.006), intensity (p = 0. Oil), pain behavior (p = 0.016), andNRS (p = 0.0004). Three patients underwen