Isolation, Characterization, and Quantification of a New Anticancer Constituent from Leaves of Nyctanthes arbor-tristis
A new compound, 1,1,2-tris(2′,4′-di-tert-butylphenyl)-4,4-dimethylpent-1-ene, was isolated and characterized from the leaves of Nyctanthes arbor-tristis L. The plant was subjected to bioactivity-guided fractionation, and a compound was isolated from chloroform extract that was found to have potent a...
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Veröffentlicht in: | Chemistry of natural compounds 2022-03, Vol.58 (2), p.193-198 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | A new compound, 1,1,2-tris(2′,4′-di-tert-butylphenyl)-4,4-dimethylpent-1-ene, was isolated and characterized from the leaves of
Nyctanthes arbor-tristis
L. The plant was subjected to bioactivity-guided fractionation, and a compound was isolated from chloroform extract that was found to have potent anticancer activity. The chloroform extract was further fractionated, and a pure compound was isolated that was found to be active against three cancer cell lines (HL-60, HCT-116, and A-549). An RP-HPLC method was developed for quantification of the isolated compound. The content of the isolated compound was 0.88% in the chloroform extract and 0.08% in
N. arbor-tristis
leaves. |
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ISSN: | 0009-3130 1573-8388 |
DOI: | 10.1007/s10600-022-03639-4 |