Two New Benzo[C]Azepin-1-Ones from Whole Plants of Thalictrum glandulosissimum and their Antibacterial Activity

Two New Benzo[C]Azepin-1-Ones from Whole Plants of Thalictrum glandulosissimum and their Antibacterial Activity

Two new benzo[c]azepin-1-ones, 2,3-dihydro-8-(3-hydroxypropyl)-4-methoxy-7-methylbenzo[c]azepin-1- one ( 1 ) and 2,3-dihydro-6-(hydroxymethyl)-8-(3-hydroxypropyl)-4-methoxybenzo[c]azepin-1-one ( 2 ), were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry of natural compounds 2022-03, Vol.58 (2), p.254-257
Hauptverfasser: Zhou, Tao, Gao, Qian, Mi, Qi-Li, Yang, Feng-Xian, Wu, Fan, Zhu, Ya-Ning, Liu, Lu, Li, Jing, Liu, Xin, Kong, Wei-Song, Yang, Guang-Yu, Hu, Qiu-Fen, Li, Xue-Mei
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial agents
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Microorganisms
NMR
Nuclear magnetic resonance
Organic Chemistry
Plant Sciences
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Two new benzo[c]azepin-1-ones, 2,3-dihydro-8-(3-hydroxypropyl)-4-methoxy-7-methylbenzo[c]azepin-1- one ( 1 ) and 2,3-dihydro-6-(hydroxymethyl)-8-(3-hydroxypropyl)-4-methoxybenzo[c]azepin-1-one ( 2 ), were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antibacterial activity. The results showed that both compounds had high antibacterial activity against 12 microbial strains isolated from the saliva of smokers.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-022-03653-6