Hemodynamic and metabolic state of hyperfixation with99mTc-HMPAO brain SPECT in subacute stroke

By means of positron emission tomography (PET), we investigated the hemodynamic and metabolic state of the hyperfixation identified as the increased accumulation with^sup 99m^Tc-d,l-hexamethylpropyleneamine oxime (HMPAO) by single photon emission computed tomography (SPECT) in patients with subacute stroke. We studied four patients with subacute stroke having hyperfixed areas evaluated with CBF, CMRO^sub 2^, OEF and CBV by PET. The hyperfixation rate with^sup 99m^Tc-HMPAO was obtained by comparing the surplus rate with standardized CBF. The OEF and CMRO^sub 2^ values in the hyperfixed areas of 4 patients were significantly lower than those in normal 5 controls (p