Pd-Catalyzed alkynyl aryl iodide cyclization/alkylation with cyclobutanols

A palladium-catalyzed cis -selective carboalkylation of internal alkynes with cyclobutanols is reported, providing a useful and facile approach to alkyl-substituted olefins with moderate to good yields and excellent stereoselectivity. The cascade process involves the intramolecular carbopalladation of internal alkynes and intermolecular trapping of vinylpalladium with cyclobutanols. This new approach has good functional group compatibility, broad substrate scope and high atom economy.