Oligocarbamates as MHC class I ligands

Oligocarbamates as MHC class I ligands

SummaryNew ligands for major histocompatibility complex (MHC) class I molecules were prepared using a flexible automated synthesis of oligocarbamates. An efficient solution-phase synthesis was found for Fmoc-amino alcohols which are required as building blocks. The biological activity of the oligome...

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Veröffentlicht in:International journal of peptide research and therapeutics 1998-05, Vol.5 (2-3), p.125-128
Hauptverfasser: Warrass, Ralf, Walden, Peter, Wiesmüller, Karl-Heinz, Jung, Günther
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Biological activity
Ligands
Major histocompatibility complex
Peptidomimetics
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Zusammenfassung:SummaryNew ligands for major histocompatibility complex (MHC) class I molecules were prepared using a flexible automated synthesis of oligocarbamates. An efficient solution-phase synthesis was found for Fmoc-amino alcohols which are required as building blocks. The biological activity of the oligomeric peptidomimetics was demonstrated in a stabilizing assay with MHC class I presenting cells.
ISSN:0929-5666
1573-3149
1573-496X
1573-3904
DOI:10.1007/BF02443453