CD4+ chimeric antigen receptor T cells in for the long journey

In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells isolated from patients over 10 years after therapy, revealing expansion of a long‐lived CD4+ CAR T‐cell population with a cytotoxic phenotype.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology and cell biology 2022-05, Vol.100 (5), p.304-307
Hauptverfasser:	Chen, Amanda XY, Derrick, Emily B, Beavis, Paul A, House, Imran G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens CD4 antigen CD4-Positive T-Lymphocytes chimeric antigen receptor T cells Chimeric antigen receptors cytotolytic CD4+ T cells Cytotoxicity Humans Immunotherapy, Adoptive Lymphocytes T persistence Phenotypes Receptors, Antigen, T-Cell Receptors, Chimeric Antigen - genetics T-Lymphocytes
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Beschreibung
Zusammenfassung:	In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells isolated from patients over 10 years after therapy, revealing expansion of a long‐lived CD4+ CAR T‐cell population with a cytotoxic phenotype.
ISSN:	0818-9641 1440-1711
DOI:	10.1111/imcb.12545