Lower Incidence of HIV-1 Blips Observed During Integrase Inhibitor–Based Combination Antiretroviral Therapy

As the nature of viral blips remains unclear, their occurrence often leads to uncertainty. This study compares blip incidence rates during treatment with different combination antiretroviral therapy anchors. Retrospective cohort study in a tertiary hospital. All antiretroviral regimens between 2010...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2022-04, Vol.89 (5), p.575-582
Hauptverfasser:	Dijkstra, Suzan, Hofstra, L. Marije, Mudrikova, Tania, Wensing, Annemarie M. J., Oomen, Patrick G. A., Hoepelman, Andy I. M., van Welzen, Berend J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active - adverse effects Confidence intervals Drug therapy Evaluation Failure HIV HIV Infections - complications HIV Integrase Inhibitors - therapeutic use HIV Seropositivity - complications HIV-1 Human immunodeficiency virus Humans Incidence Integrase Non-nucleoside reverse transcriptase inhibitors Protease inhibitors Proteinase inhibitors Retrospective Studies Reverse Transcriptase Inhibitors - therapeutic use RNA-directed DNA polymerase Therapy Viral Load Viremia Viremia - drug therapy
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Beschreibung
Zusammenfassung:	As the nature of viral blips remains unclear, their occurrence often leads to uncertainty. This study compares blip incidence rates during treatment with different combination antiretroviral therapy anchors. Retrospective cohort study in a tertiary hospital. All antiretroviral regimens between 2010 and 2020 containing 2 nucleos(-t)ide reverse transcriptase inhibitors and 1 anchor in virologically suppressed people living with HIV (PLWH) from our center were evaluated for the occurrence of blips [isolated viral loads (VLs) 50-499 copies/mL between measurements
ISSN:	1525-4135 1944-7884
DOI:	10.1097/QAI.0000000000002898