Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates
New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[ b ]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2 H )-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carbonitrile with alcohols. The structures of the compounds obtained were co...
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Veröffentlicht in: | Russian chemical bulletin 2022-03, Vol.71 (3), p.538-542 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
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Zusammenfassung: | New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[
b
]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2
H
)-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[
b
]thiophene-3-carbonitrile with alcohols. The structures of the compounds obtained were confirmed by
1
H and
13
C NMR spectroscopy and elemental analysis. A number of new compounds were found to have a pronounced analgesic activity, as well as a weak antimicrobial effect or its absence. |
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ISSN: | 1066-5285 1573-9171 |
DOI: | 10.1007/s11172-022-3445-y |