Synthesis, analgesic and antimicrobial activity of substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates

New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[ b ]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2 H )-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carbonitrile with alcohols. The structures of the compounds obtained were co...

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Veröffentlicht in:Russian chemical bulletin 2022-03, Vol.71 (3), p.538-542
Hauptverfasser: Sharavyeva, Yu. O., Siutkina, A. I., Chashchina, S. V., Novikova, V. V., Makhmudov, R. R., Shipilovskikh, S. A.
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Sprache:eng
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Zusammenfassung:New substituted 2-(3-cyano-4,5,6,7-tetrahydrobenzo[ b ]thiophen-2-ylamino)-4-oxo-4-phenylbut-2-enoates were obtained by the reaction of 2-((2-oxo-5-phenylfuran-3(2 H )-ylidene)-amino)-4,5,6,7-tetrahydrobenzo[ b ]thiophene-3-carbonitrile with alcohols. The structures of the compounds obtained were confirmed by 1 H and 13 C NMR spectroscopy and elemental analysis. A number of new compounds were found to have a pronounced analgesic activity, as well as a weak antimicrobial effect or its absence.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-022-3445-y