Palladium(II) – Catalyzed Functionalization of Aromatic Amines with Aliphatic Aziridines: Direct Approach to Form O‐Aminophenethylamine Backbones

Palladium(II) – Catalyzed Functionalization of Aromatic Amines with Aliphatic Aziridines: Direct Approach to Form O‐Aminophenethylamine Backbones

A palladium‐catalyzed cross‐coupling of an ortho‐C(sp2) atom of aromatic amines with aliphatic aziridines to construct the O‐aminophenethylamine skeleton via C−H activation has been developed. The reaction proceeded under mild conditions with good substrate scope. The O‐aminophenethylamine skeleton...

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Veröffentlicht in:Advanced synthesis & catalysis 2022-04, Vol.364 (9), p.1555-1563
Hauptverfasser: He, Shuo, Chen, Yujie, Huang, Zhi‐Bin, Li, Bao, Shi, Da‐Qing, Zhao, Yingsheng
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Amines
aromatic amine
aziridines
Cross coupling
C−C bond formation
C−H activation
Palladium
palladium catalyst
Substrates
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Zusammenfassung:A palladium‐catalyzed cross‐coupling of an ortho‐C(sp2) atom of aromatic amines with aliphatic aziridines to construct the O‐aminophenethylamine skeleton via C−H activation has been developed. The reaction proceeded under mild conditions with good substrate scope. The O‐aminophenethylamine skeleton in drugs or bioactive compounds could be generated in one step in this report.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202101491