Ruthenium‐Catalyzed C7‐Formylmethylation or Sequential Acetalization of Indolines with Vinylene Carbonate in Different Solvents

The ruthenium‐catalyzed C7‐formylmethylation or sequential acetalization of indolines with vinylene carbonate has been realized under simple and easy‐to‐operate reaction systems. Several preliminary mechanistic studies and derivatization reactions for the conversion of formylmethyl group were also p...

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Veröffentlicht in:	Advanced synthesis & catalysis 2022-04, Vol.364 (9), p.1580-1586
Hauptverfasser:	Liu, Min, Yan, Kelu, Wen, Jiangwei, Shang, Wenda, Sui, Xinlei, Wang, Xiu
Format:	Artikel
Sprache:	eng
Schlagworte:	C−H activation Direct conversion formylmethylation Heterocyclic compounds indolines Ruthenium vinylene carbonate
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Beschreibung
Zusammenfassung:	The ruthenium‐catalyzed C7‐formylmethylation or sequential acetalization of indolines with vinylene carbonate has been realized under simple and easy‐to‐operate reaction systems. Several preliminary mechanistic studies and derivatization reactions for the conversion of formylmethyl group were also performed. This transformation offers an alternative approach for the direct conversion of C(sp2)−H to formylmethyl or corresponding acetal structure.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.202200082