One‐Pot Manganese (IV)‐Mediated Synthesis of Sulfonyl Fluorides from Arylhydrazines

Sulfonyl fluorides, a useful structure in various organic syntheses, are found in several biologically active molecules and have been used in sulfur (VI) fluoride exchange‐based “click chemistry”. In the present study, a novel MnO2‐mediated synthetic method to prepare sulfonyl fluorides from aryl hydrazines employing DABSO and NFSI as effective reagents affording a variety of sulfonyl fluoride products in good to excellent yields is described. Our results suggest the generality of this MnO2 mediated transformation of various aryl hydrazines into sulfonyl fluorides under mild reaction conditions. Direct MnO2‐mediated synthesis of aryl sulfonyl fluorides from aryl hydrazine hydrochlorides is developed. This synthetic method successfully afforded a variety of aryl sulfonyl fluorides in high yields via treatment with DABSO and NFSI under mild reaction conditions.