CD8+ mycosis fungoides with ichthyosiform clinical presentation and angiocentric feature

Mycosis fungoides (MF) is characterized by epidermotropic atypical lymphocytes infiltrate with α/β T‐helper memory immunophenotype (βF1+, CD3+, CD4+, CD45Ro+, and CD8−). Angiocentricity is always associated with aggressive behavior or poor outcome in primary or secondary cutaneous lymphomas. Rare cases of angiocentric MF with a T‐cytotoxic immunophenotype (CD3+, CD4−, CD8+, TIA‐1+) have been described. Here, we report a 27‐year‐old man diagnosed with MF, clinically presenting with ichthyosiform lesions on his trunk and limbs. Biopsy demonstrated a CD3+ and CD8+ atypical lymphocytic infiltrate with marked epidermotropism and angiocentricity. Awareness of this rare MF variant with unusual clinicopathological characteristics is important to avoid misdiagnosis.