Copper(I)-Catalyzed Click Chemistry-Based Synthesis and Antimicrobial Evaluation of Triazolopyridine–Triazole Congeners

In an effort to find a new pharmacologically dynamic molecule, we report here the synthesis and in vitro antimicrobial activity of N -phenyl-2-(4-{[(3 H -[1,2,3]triazolo[4,5- b ]pyridin-3-yl)oxy]methyl}-1 H -1,2,3-triazol-1-yl)-acetamides. These compounds were synthesized through copper(I)-catalyzed 1,3-dipolar cyclo­addition reaction of 3-(prop-2-yn-1-yloxy)-3 H -[1,2,3]triazolo[4,5- b ]pyridine and different 2-azido- N -(substi­tuted phenyl)acetamide derivatives according to the click chemistry approach. Traditional spectroscopic techniques such as IR, 1 H and 13 C NMR, and MS were employed for structural confirmation. The synthesized compounds were screened for their antibacterial and antifungal activities on a group of gram-positive bacteria, gram-negative bacteria, and fungi strains by the disc diffusion method. Some of the compounds showed significant potency and biocompatibility.