Design, simulation and application of cell migration of multi-channel microfluidic chip

Cell migration refers to the directional migration of cells towards a specific chemical concentration gradient, which plays a crucial role in embryonic development, wound healing, and tumor metastasis. Most of the current research methods have low throughput, and it is difficult to comprehensively consider the effect of different concentration gradient conditions on cell migration behavior. In response to the above problems, this paper first designs a four-channel microfluidic chip, which is characterized as follows: the concentration gradient is established and maintained in the main channel of cell migration by means of laminar flow and diffusion mechanism; four groups of cells can be observed simultaneously under a single microscope field of view Migration phenomenon; a cell isolation strip with a width of 20 μm is integrated, which can calibrate the initial position of the cells and ensure the accuracy of the experimental results. Subsequently, the simulation analysis of the microfluidic chip was complete