Synthesis and Cytotoxic Activity of Tetrazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones

Synthesis and Cytotoxic Activity of Tetrazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones

Tetrazole-containing 1,5,6,7-tetrahydro-4 H- indazol-4-ones were synthesized by condensation of 2-(tetrazolylacetyl)cyclohexane-1,3-diones with phenyl- or 4-fluorophenylhydrazines in ethanol at room temperature. Structure of the synthesized compounds were confirmed by 1 H, 13 C, 19 F NMR spectroscop...

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Veröffentlicht in:Russian journal of general chemistry 2022-03, Vol.92 (3), p.359-366
Hauptverfasser: Khlebniсova, T. S., Zinovich, V. G., Piven, Yu. A., Baranovsky, A. V., Lakhvich, F. A., Trifonov, R. E., Golubeva, Yu. A., Lider, E. V.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cyclohexane
Cytotoxicity
Ethanol
NMR spectroscopy
Nuclear magnetic resonance spectroscopy
Room temperature
Synthesis
Tetrazoles
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Zusammenfassung:Tetrazole-containing 1,5,6,7-tetrahydro-4 H- indazol-4-ones were synthesized by condensation of 2-(tetrazolylacetyl)cyclohexane-1,3-diones with phenyl- or 4-fluorophenylhydrazines in ethanol at room temperature. Structure of the synthesized compounds were confirmed by 1 H, 13 C, 19 F NMR spectroscopy methods. Cytotoxic activity of the series of obtained compounds was investigated in vitro against human laryngeal cancer cells Hep2.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363222030045