Nanophotonics Enable Targeted Photothermal Silencing of Nociceptor Neurons (Small 14/2022)

Nanophotonics Enable Targeted Photothermal Silencing of Nociceptor Neurons (Small 14/2022)

Nociceptor Neuron Silencing In article number 2103364, Sebastien Talbot, Christos Boutopoulos, and co‐workers report a nanotechnology‐enabled strategy to silence subsets of unmodified nociceptor neurons. It uses laser stimulation of neurons targeted with gold nanoparticles to heat‐activate TRPV1, tu...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2022-04, Vol.18 (14), p.n/a
Hauptverfasser: Roversi, Katiane, Tabatabaei, Maryam, Desjardins‐Lecavalier, Nicolas, Balood, Mohammad, Crosson, Theo, Costantino, Santiago, Griffith, May, Talbot, Sebastien, Boutopoulos, Christos
Format: Artikel
Sprache:eng
Schlagworte:
functionalized gold nanoparticles
Nanoparticles
nanophotonics
Nanotechnology
Neurons
nociceptor neurons
N‐type calcium channel blocker (CNCB‐2)
photothermal silencing
targeted drug delivery
transient receptor potential vanilloid type 1 (TRPV1)
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Zusammenfassung:Nociceptor Neuron Silencing In article number 2103364, Sebastien Talbot, Christos Boutopoulos, and co‐workers report a nanotechnology‐enabled strategy to silence subsets of unmodified nociceptor neurons. It uses laser stimulation of neurons targeted with gold nanoparticles to heat‐activate TRPV1, turning this channel into a cell‐specific entry port for silencing drugs that block neuropeptide release (i.e., communication with other cells). This work establishes a paradigm for interfering with deleterious neuro‐immune interplays.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202270067