Renoprotective effects of Adansonia digitata leaf extract on renal function and histopathological changes in vancomycin-induced nephrotoxicity in Wistar rats

The study targeted investigation of renoprotective ability of the Adansonia digitata on renal function and histopathological changes in vancomycin-induced nephrotoxicity in Wistar rats. Thirty (30) male Wistar rats (125 ± 0.3 g) were grouped into six of five each: (1) normal control, (2) received 200 mg/kg of VCM only, (3) 200 mg/kg VCM + 200 mg/kg of A. digitata extract, (4) 200 mg/kg VCM + 400 mg/kg of A. digitata extract, (5) 200 mg/kg VCM + vitamin E 1000 IU/kg, and (6) 200 mg/kg + 25 mg/kg of hydrochlorothiazide (HCT). VCM was intraperitoneally administered twice a day for 14 days. Vitamin E was injected 5 min prior to every vancomycin injection. Blood and kidneys obtained were prepared for the determination of the parameters and histopathological studies, respectively. Creatinine and urea concentrations were significantly ( p > 0.01) decreased across the test groups as against group 2 (VCM only). Variations of serum electrolytes were recorded against group 2 (VCM only). Total protein significantly ( p