Tuning the signal: ATP-sensitive K + channels direct blood flow to cerebral capillaries

Tuning the signal: ATP-sensitive K + channels direct blood flow to cerebral capillaries

Cerebral blood flow must be exquisitely regulated to match the metabolic demands of neurons. In this issue of , Sancho characterize functional ATP-sensitive K (K ) channels in cerebral capillary endothelial cells and pericytes that can be activated by adenosine signaling, thereby leading to increase...

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Veröffentlicht in:Science signaling 2022-03, Vol.15 (727), p.eabo1118
1. Verfasser: Jackson, William F
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine - metabolism
Adenosine Triphosphate - metabolism
Blood flow
Capillaries
Capillaries - metabolism
Endothelial Cells - metabolism
Pericytes - metabolism
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Zusammenfassung:Cerebral blood flow must be exquisitely regulated to match the metabolic demands of neurons. In this issue of , Sancho characterize functional ATP-sensitive K (K ) channels in cerebral capillary endothelial cells and pericytes that can be activated by adenosine signaling, thereby leading to increases in capillary blood flow.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.abo1118