Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity
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| Veröffentlicht in: | Leukemia 2006-05, Vol.20 (5), p.881-883 |
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| container_title | Leukemia |
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| creator | Mathews, V Desire, S George, B Lakshmi, K M Rao, J G Viswabandya, A Bajel, A Srivastava, V M Srivastava, A Chandy, M |
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| doi_str_mv | 10.1038/sj.leu.2404165 |
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Tests ; Male ; Medicine ; Medicine & Public Health ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Oncology ; Oxides - administration & dosage ; Oxides - adverse effects ; Oxides - therapeutic use ; Polymorphism, Genetic ; Promyeloid leukemia ; Remission Induction ; Risk Factors ; Survival Rate ; Treatment Outcome</subject><ispartof>Leukemia, 2006-05, Vol.20 (5), p.881-883</ispartof><rights>Springer Nature Limited 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2006</rights><rights>Nature Publishing Group 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S</creatorcontrib><creatorcontrib>George, B</creatorcontrib><creatorcontrib>Lakshmi, K M</creatorcontrib><creatorcontrib>Rao, J G</creatorcontrib><creatorcontrib>Viswabandya, A</creatorcontrib><creatorcontrib>Bajel, A</creatorcontrib><creatorcontrib>Srivastava, V M</creatorcontrib><creatorcontrib>Srivastava, A</creatorcontrib><creatorcontrib>Chandy, M</creatorcontrib><title>Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><subject>Acute promyeloid leukemia</subject><subject>Adult</subject><subject>Arsenic</subject><subject>Arsenic trioxide</subject><subject>Arsenicals - administration & dosage</subject><subject>Arsenicals - adverse effects</subject><subject>Arsenicals - therapeutic use</subject><subject>Cancer Research</subject><subject>Chemical and Drug Induced Liver Injury - complications</subject><subject>Chemical and Drug Induced Liver Injury - drug therapy</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Cohort Studies</subject><subject>Critical Care Medicine</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Hematology</subject><subject>Hepatotoxicity</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>letter-to-the-editor</subject><subject>Leukemia</subject><subject>Leukemia, Promyelocytic, Acute - diagnosis</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - genetics</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - pathology</subject><subject>Liver Function Tests</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Oncology</subject><subject>Oxides - administration & dosage</subject><subject>Oxides - adverse effects</subject><subject>Oxides - therapeutic use</subject><subject>Polymorphism, Genetic</subject><subject>Promyeloid leukemia</subject><subject>Remission Induction</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>Treatment 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profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity</title><author>Mathews, V ; Desire, S ; George, B ; Lakshmi, K M ; Rao, J G ; Viswabandya, A ; Bajel, A ; Srivastava, V M ; Srivastava, A ; Chandy, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-a3a2f68316f3825d30495cc8461a5399678f19619bff84fe9cf6a2c21a6b43c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acute promyeloid leukemia</topic><topic>Adult</topic><topic>Arsenic</topic><topic>Arsenic trioxide</topic><topic>Arsenicals - administration & dosage</topic><topic>Arsenicals - adverse effects</topic><topic>Arsenicals - therapeutic use</topic><topic>Cancer Research</topic><topic>Chemical and Drug Induced Liver Injury - complications</topic><topic>Chemical and Drug Induced Liver Injury - drug therapy</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Cohort Studies</topic><topic>Critical Care Medicine</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Hematology</topic><topic>Hepatotoxicity</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>letter-to-the-editor</topic><topic>Leukemia</topic><topic>Leukemia, Promyelocytic, Acute - diagnosis</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - genetics</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - pathology</topic><topic>Liver Function Tests</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public 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| ispartof | Leukemia, 2006-05, Vol.20 (5), p.881-883 |
| issn | 0887-6924 1476-5551 |
| language | eng |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Acute promyeloid leukemia Adult Arsenic Arsenic trioxide Arsenicals - administration & dosage Arsenicals - adverse effects Arsenicals - therapeutic use Cancer Research Chemical and Drug Induced Liver Injury - complications Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - etiology Cohort Studies Critical Care Medicine Disease-Free Survival Female Follow-Up Studies Gene polymorphism Genetic Predisposition to Disease Hematology Hepatotoxicity Humans Incidence Intensive Internal Medicine letter-to-the-editor Leukemia Leukemia, Promyelocytic, Acute - diagnosis Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Liver - drug effects Liver - enzymology Liver - pathology Liver Function Tests Male Medicine Medicine & Public Health Methylenetetrahydrofolate Reductase (NADPH2) - genetics Oncology Oxides - administration & dosage Oxides - adverse effects Oxides - therapeutic use Polymorphism, Genetic Promyeloid leukemia Remission Induction Risk Factors Survival Rate Treatment Outcome |
| title | Hepatotoxicity profile of single agent arsenic trioxide in the treatment of newly diagnosed acute promyelocytic leukemia, its impact on clinical outcome and the effect of genetic polymorphisms on the incidence of hepatotoxicity |
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