Electrochemical Sensor Based on a Modified Graphite Screen Printed Electrode for Amitriptyline Determination
In this study, a graphene oxide (GO)/Fe 3 O 4 @SiO 2 nanocomposite was synthesized and used to modify a graphite screen printed electrode (GSPE) by drop casting, a simple and easy technique, in order to electrochemically detect amitriptyline. Electrooxidation of amitriptyline was studied on the GO/F...
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Veröffentlicht in: | Surface engineering and applied electrochemistry 2022-02, Vol.58 (1), p.100-108 |
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Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | In this study, a graphene oxide (GO)/Fe
3
O
4
@SiO
2
nanocomposite was synthesized and used to modify a graphite screen printed electrode (GSPE) by drop casting, a simple and easy technique, in order to electrochemically detect amitriptyline. Electrooxidation of amitriptyline was studied on the GO/Fe
3
O
4
@SiO
2
/GSPE using cyclic voltammetry, linear sweep voltammetry, differential pulse voltammetry, and chronoamperometry. The oxidation peak potential of amitriptyline on the GO/Fe
3
O
4
@SiO
2
/GSPE appeared at 800 mV, which was accompanied with a lower overpotential and an increase in the oxidation peak current compared to that obtained on a bare GSPE. Under the optimized conditions, the method used in preparation showed a good dynamic concentration range from 2.0 to 1000.0 µM, with a limit of detection 0.5 µM. The modified electrode was successfully applied to amitriptyline determination in real samples. |
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ISSN: | 1068-3755 1934-8002 |
DOI: | 10.3103/S1068375522010070 |