Cyclosporin A-related cerebral vasculopathy

The use of cyclosporin A has been associated with several side-effects, including neurotoxicity. The mechanism of toxicity is not well known. We report two patients treated with cyclosporin A who developed lesions in the cerebral white matter associated with abnormally elevated cerebral blood flow v...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2000-10, Vol.26 (7), p.801-804
Hauptverfasser:	SHBAROU, R. M, CHAO, N. J, MORGENLANDER, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiography Biological and medical sciences Blood flow Blood Flow Velocity Bone marrow Bone marrow transplantation Cerebral Angiography Cerebral blood flow Cerebrovascular Disorders - chemically induced Cerebrovascular Disorders - diagnosis Cerebrovascular Disorders - etiology Crohn Disease - complications Crohn Disease - drug therapy Cyclosporin A Cyclosporine - toxicity Doppler effect Drug toxicity and drugs side effects treatment Female Flow velocity Humans Magnetic resonance Magnetic Resonance Imaging Medical sciences Myelodysplastic Syndromes - complications Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - therapy Neurotoxicity Pharmacology. Drug treatments Stem cell transplantation Substantia alba Toxicity Toxicity: nervous system and muscle Transplantation Ultrasonics Ultrasound Vascular diseases
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Zusammenfassung:	The use of cyclosporin A has been associated with several side-effects, including neurotoxicity. The mechanism of toxicity is not well known. We report two patients treated with cyclosporin A who developed lesions in the cerebral white matter associated with abnormally elevated cerebral blood flow velocities on transcranial doppler ultrasound and abnormal vascular appearance on magnetic resonance angiography. Bone Marrow Transplantation (2000) 26, 801-804.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1702603