The hemochromatosis C282Y allele : a risk factor for hepatic veno-occlusive disease after hematopoietic stem cell transplantation

Hepatic veno-occlusive disease (HVOD) is a serious complication of hematopoietic stem cell transplantation (HSCT). Since the liver is a major site of iron deposition in HFE-associated hemochromatosis, and iron has oxidative toxicity, we hypothesized that HFE genotype might influence the risk of HVOD...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2005-06, Vol.35 (12), p.1155-1164
Hauptverfasser:	KALLIANPUR, A. R, HALL, L. D, YADAV, M, BYRNE, D. W, SPEROFF, T, DITTUS, R. S, HAINES, J. L, CHRISTMAN, B. W, SUMMAR, M. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Breast Neoplasms - complications Breast Neoplasms - therapy Carbamoyl-Phosphate Synthase (Ammonia) - genetics Care and treatment Causes of Chelation Complications and side effects Diagnosis Enzymes Female Genetic aspects Genetic Predisposition to Disease - epidemiology Genotype Genotypes Hematologic Neoplasms - complications Hematologic Neoplasms - therapy Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic stem cells Hemochromatosis Hemochromatosis - genetics Hepatic Veno-Occlusive Disease - etiology Hepatic Veno-Occlusive Disease - genetics Hepatic Veno-Occlusive Disease - metabolism Heterozygotes Homozygotes Humans Iron Iron - metabolism Liver diseases Male Medical sciences Metabolic diseases Metals (hemochromatosis...) Middle Aged Mutation, Missense Other metabolic disorders Oxidative stress Polymorphism, Genetic Polymorphism, Single-Stranded Conformational Prospective Studies Risk analysis Risk Factors Stem cell transplantation Stem cells Toxicity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Urea Ureas Veno-occlusive disease
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