Severe cutaneous ulceration following treatment with thalidomide for GVHD

We report two cases of severe leg ulcerations in patients being treated with thalidomide for graft-versus-host disease following bone marrow transplantation. Local wound care and debridement were attempted, but one patient required skin grafting to ensure healing. We propose that this complication m...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2001, Vol.27 (2), p.229-230
Hauptverfasser:	SCHLOSSBERG, H, KLUMPP, T, SABOL, P, HERMAN, J, MANGAN, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiogenesis Antiangiogenics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Bone marrow Bone marrow transplantation Bone Marrow Transplantation - adverse effects Combined Modality Therapy Drug toxicity and drugs side effects treatment Female Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft-versus-host reaction Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use Leukemia, Lymphocytic, Chronic, B-Cell - therapy Male Medical sciences Middle Aged Patients Pharmacology. Drug treatments Skin Skin grafts Skin Ulcer - etiology Stem cell transplantation Thalidomide Thalidomide - adverse effects Thalidomide - therapeutic use Toxicity: skin, dermoskeleton Transplantation Transplantation, Homologous
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Zusammenfassung:	We report two cases of severe leg ulcerations in patients being treated with thalidomide for graft-versus-host disease following bone marrow transplantation. Local wound care and debridement were attempted, but one patient required skin grafting to ensure healing. We propose that this complication may be due to the antiangiogenic properties of thalidomide and urge careful attention to skin breakdown in patients being treated with this compound.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/sj.bmt.1702756