Magnetic Nanoparticles Obtained by Electrophysical Technique: Focus on Biomedical Applications

The possibilities of producing large batches of magnetic nanoparticles (MNPs) using electrical explocion of the wire (EEW), laser target evaporation, and spark discharge are considered. MNP bioapplications require production of magnetic materials in the form of as stabilized aqueous suspensions or hydrogels with magnetic fillers; therefore, some details of synthesis of these materials and their certification are discussed. The problems of the interaction of MNPs with biological systems, biocompatibility, the applicability of ferrogel substrata to cellular technology and regenerative medicine, and as biomimetics in the development of magnetic biosensors are considered. The results of analysis of some biological experiments with various suspensions prepared based on the same MNP batch are presented. An analysis of the examples of magnetic biodetection and existing theoretical approaches will allow estimation of prospects of this scientific direction to develop highly sensitive film sensors based on the giant magnetic impedance effect for biomedical applications.