Cobalt-catalyzed cascade hydroalkenylation of 1,6-enynes with chalcones

Cobalt-catalyzed cascade hydroalkenylation of 1,6-enynes with chalcones

An efficient stereoselective cobalt-catalyzed hydrovinylative cyclization of 1,6-enynes with chalcones to obtain functionalized pyrrolidines has been developed. The products were furnished in good yields with up to 93% ee. A plausible mechanism through which the transformation was initiated by cycli...

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Veröffentlicht in:Organic Chemistry Frontiers 2022-03, Vol.9 (6), p.1616-1620
Hauptverfasser: Pan, Chunxiang, Wang, Gaowei, Zhao, Hengyuan, Ni, Jianxiao, Fan, Ruifeng, Zhou, Yongyun, Zhu, Yuanbin, Wu, Shiyuan, Fan, Baomin
Format: Artikel
Sprache:eng
Schlagworte:
Cobalt
Organic chemistry
Stereoselectivity
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Zusammenfassung:An efficient stereoselective cobalt-catalyzed hydrovinylative cyclization of 1,6-enynes with chalcones to obtain functionalized pyrrolidines has been developed. The products were furnished in good yields with up to 93% ee. A plausible mechanism through which the transformation was initiated by cyclization of 1,6-enynes is proposed.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/D1QO01450A