Comparative effects of nebivolol and atenolol on blood pressure and insulin sensitivity in hypertensive subjects with type II diabetes

The aim of this double-blind, parallel group study was to compare the effects of nebivolol and atenolol on blood pressure (BP) and insulin sensitivity in hypertensive patients with type II, non-insulin dependent diabetes mellitus (NIDDM). After a 4-week run-in period on placebo, 30 patients (14 male...

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Veröffentlicht in:	Journal of human hypertension 1997-11, Vol.11 (11), p.753-757
Hauptverfasser:	FOGARI, R, ZOPPI, A, LAZZARI, P, MUGELLINI, A, LUSARDI, P, PRETI, P, VAN NUETEN, L, VERTOMMEN, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - adverse effects Adrenergic beta-Antagonists - therapeutic use Adult Aged Antihypertensive agents Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use Atenolol Atenolol - adverse effects Atenolol - therapeutic use Benzopyrans - adverse effects Benzopyrans - therapeutic use Biological and medical sciences Blood pressure Blood Pressure - drug effects Carbohydrate metabolism Cardiovascular system Cholesterol Diabetes Diabetes mellitus (insulin dependent) Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Diabetic Angiopathies - drug therapy Diabetic Angiopathies - physiopathology Double-Blind Method Ethanolamines - adverse effects Ethanolamines - therapeutic use Female Glucose Glucose metabolism Humans Hypertension Hypertension - drug therapy Insulin Insulin Resistance Low density lipoprotein Male Medical sciences Middle Aged Nebivolol Patients Peptides Pharmacology. Drug treatments Placebos Plasma levels Sensitivity analysis Single-Blind Method Triglycerides
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Beschreibung
Zusammenfassung:	The aim of this double-blind, parallel group study was to compare the effects of nebivolol and atenolol on blood pressure (BP) and insulin sensitivity in hypertensive patients with type II, non-insulin dependent diabetes mellitus (NIDDM). After a 4-week run-in period on placebo, 30 patients (14 males and 16 females) aged 43 to 69 years, with stable NIDDM and mild to moderate hypertension (DBP > or =95 and
ISSN:	0950-9240 1476-5527
DOI:	10.1038/sj.jhh.1000533