Dehydrogenation of N‐Heterocyclic Compounds Using H2O2 and Mediated by Polar Solvents

The oxidative dehydrogenation of N‐heterocyclic compounds by using H2O2 as oxidant in combination with polar solvents such as 1,1,1,3,3,3‐hexafluoroisopropanol (HFIP) and H2O is described. Among these two solvents, the best yields for the heteroaromatic compounds were generally achieved in HFIP. However, it is remarkable, that the use of a non toxic solvent such as H2O gave such good yields. Furthermore, the procedure was implemented in larger‐scale and HFIP was distilled from the reaction mixture and reused (up to 5 cycles) without a significant detriment in the reaction outcome.