Preparation and Study of Properties of a New Biocomposite of Chitosan with 5,7-Bis(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-8-hydroxyquinoline

A new bioorganic composite was obtained by impregnation of 5,7-bis(1-hydroxy-1-trifluoromethyl-2,2,2-trifluoroethyl)-8-hydroxyquinoline (FOQ) into chitosan in 60% acetic acid. The resulting complex was found to be highly stable due to hydrogen bonding between the amino groups of chitosan and the highly acidic OH groups of FOQ. This composite inhibited the growth of gram-positive and gram-negative bacteria to a much greater extent than pristine chitosan. It is expected that the biocomposite would be used as an antibacterial coating with a prolonged service life for collagen matrices used for cardiac prostheses.