Molecular Investigation of Carbapenem and Colistin Resistance Mechanisms in Klebsiella pneumoniae Bloodstream Isolates

Received: 18.08.2021 Revised: 05.09.2021 Accepted: 01.10.2021 INTRODUCTION Antibiotic resistance of Gram-negative bacteria has become a concern for public health. ESBL-producing Kp has been reported as resistant to cephalosporins and various antibiotics, including quinolones (Mugnaioli, 2006). [...]carbapenems have been proposed for the treatment of ESBL-producing Kp infections. According to the Ambler classification, these carbapenemases are divided into three groups; class A (K. pneumoniae carbapenemase, KPC), class B (Metallo-ß-lactamases, NDM), and class D (oxacilinases, OXA-48-like) (Pitout, 2015). [...]those with MIC values > 2 mg / L were considered resistant to colistin, while those 2 mg / L were deemed to be sensitive to colistin.