MIL-47(V) catalytic conversion of H2O2 for sensitive H2O2 detection and tumor cell inhibition

Rapid in situ monitoring of hydrogen peroxide (H2O2) released from living cells is of great significance for the early diagnosis, case analysis, and treatment of tumors. In this work, a sensitive MIL-47(V)-OH monitoring sensor was designed by adjusting the ligand of MIL-47(V) to realize the rapid in-situ detection of H2O2 released from living cells with high selectivity. The working potential of the as-designed sensor was optimized, and the electrochemical reaction products of H2O2 under different working potentials were analyzed by electron paramagnetic resonance (EPR). Even without an applied voltage, MIL-47(V)-OH can convert H2O2 into ·O2−, which validates its ability to inhibit tumor cells. Hence, MIL-47(V)-OH is a promising material for H2O2 detection, tumor cell inhibition, and thus, application in biological diagnoses and oncology therapy. Through the ligand regulating of the MIL-47(V), MIL-47(V)-OH was fabricated and delivered rapid in-situ sensing H2O2 released by living cells, and good tumor cell inhibition. [Display omitted] •A simple electrochemical sensor was constructed to in situ detect H2O2 released from cells.•The sensing speed of MIL-47(V) toward H2O2 can be accelerated by adjusting the ligand of MOF.•EPR was used to analyze the electro-chemical reaction products of H2O2, and the tested potential is also optimized.•The MIL-47(V)-OH can be used to inhibit tumour cells.