Novel rhino-like SHJHhr mice with thyroid dysfunction

[...]based on the above results, we successfully established a novel mouse model with thyroid dysfunction. Female SHJHftr mice had mildly lower MAP, SBP, and diastolic blood pressure (DBP) than female ICR mice (Supplementary Figure S1). [...]SHJHftr mice had higher heart rate and lower blood pressure. In humans, hyperthyroidism shows high metabolism and tachycardia (De Leo et al., 2016). [...]we speculated that SHJHftr mice with higher metabolic and heart rates may have abnormal thyroid function. Previous studies have confirmed that the Hr gene is involved in thyroid hormone regulation and interacts with the thyroid hormone receptor to form a transcription complex with ROR and VDR (Thompson & and back, then increase gradually, especially in female mice that have given birth. [...]SHJHftr mice display similar characteristics to rhino mice regarding hair shedding (Ahmad et al., 1998b; Ahmad et al., 1998c) and show faster skin aging compared with ICR mice.