Two-dimensional Imaging of a Model Pharmaceutical Dosage Tablet Using a Scanning Vibrational Circular Dichroism System
A vibrational circular dichroism (VCD) system with a quantum-cascade laser was used to obtain a two-dimensional image of VCD signals on a pharmaceutical tablet. A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides...
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| Veröffentlicht in: | Chemistry letters 2022-02, Vol.51 (2), p.205-207 |
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| container_end_page | 207 |
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| container_issue | 2 |
| container_start_page | 205 |
| container_title | Chemistry letters |
| container_volume | 51 |
| creator | Sato, Hisako Aisawa, Sumio Ida, Honoka Shimizu, Masaru Watanabe, Keisuke Koshoubu, Jun Yoshida, Jun Kawamura, Izuru |
| description | A vibrational circular dichroism (VCD) system with a quantum-cascade laser was used to obtain a two-dimensional image of VCD signals on a pharmaceutical tablet. A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides as excipients. VCD spectra were obtained in the range 1500–1700 cm−1 at a 1 mm i.d. spatial resolution. The results demonstrated the utility of the proposed system in quality control during drug manufacturing. |
| doi_str_mv | 10.1246/cl.210635 |
| format | Article |
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A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides as excipients. VCD spectra were obtained in the range 1500–1700 cm−1 at a 1 mm i.d. spatial resolution. 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A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides as excipients. VCD spectra were obtained in the range 1500–1700 cm−1 at a 1 mm i.d. spatial resolution. The results demonstrated the utility of the proposed system in quality control during drug manufacturing.</description><subject>Dichroism</subject><subject>Dosage</subject><subject>Hydroxides</subject><subject>Pharmaceuticals</subject><subject>Phenylalanine</subject><subject>Quality control</subject><subject>Quantum cascade lasers</subject><subject>Reagents</subject><subject>Spatial resolution</subject><subject>Tartaric acid</subject><subject>Two dimensional models</subject><issn>0366-7022</issn><issn>1348-0715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNplkD1PwzAQQC0EEqUw8A8sMTGk-COxkxG1fFQqAqkta3SxndZVEhc7AfXfk6iVGJjuhndPp4fQLSUTymLxoKoJo0Tw5AyNKI_TiEianKMR4UJEkjB2ia5C2BFC0oyzEfpe_bhI29o0wboGKjyvYWObDXYlBvzmtKnwxxZ8Dcp0rVU9MXMBNgavoKhMi9dhoAEvFTTNsH7awkN7lE2tV10FHs-s2npnQ42Xh9Ca-hpdlFAFc3OaY7R-flpNX6PF-8t8-riIFJekjWJKjGQpLaFURsSapVmhCXCaEiO45iojUkuhs1QpZrQ2JYCgWtACyjgrEj5Gd0fv3ruvzoQ237nO96-FnIk-j5QikT11f6SUdyF4U-Z7b2vwh5ySfMiaqyo_Zu1ZcWK3ph56BKesaQ872EPzZ_9_-AuYHn6o</recordid><startdate>20220205</startdate><enddate>20220205</enddate><creator>Sato, Hisako</creator><creator>Aisawa, Sumio</creator><creator>Ida, Honoka</creator><creator>Shimizu, Masaru</creator><creator>Watanabe, Keisuke</creator><creator>Koshoubu, Jun</creator><creator>Yoshida, Jun</creator><creator>Kawamura, Izuru</creator><general>The Chemical Society of Japan</general><general>Chemical Society of Japan</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20220205</creationdate><title>Two-dimensional Imaging of a Model Pharmaceutical Dosage Tablet Using a Scanning Vibrational Circular Dichroism System</title><author>Sato, Hisako ; Aisawa, Sumio ; Ida, Honoka ; Shimizu, Masaru ; Watanabe, Keisuke ; Koshoubu, Jun ; Yoshida, Jun ; Kawamura, Izuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-410e7281fafce64d289bd0a3180e63d3c907d76d98cc2eddefaa61d61baf49b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Dichroism</topic><topic>Dosage</topic><topic>Hydroxides</topic><topic>Pharmaceuticals</topic><topic>Phenylalanine</topic><topic>Quality control</topic><topic>Quantum cascade lasers</topic><topic>Reagents</topic><topic>Spatial resolution</topic><topic>Tartaric acid</topic><topic>Two dimensional models</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Hisako</creatorcontrib><creatorcontrib>Aisawa, Sumio</creatorcontrib><creatorcontrib>Ida, Honoka</creatorcontrib><creatorcontrib>Shimizu, Masaru</creatorcontrib><creatorcontrib>Watanabe, Keisuke</creatorcontrib><creatorcontrib>Koshoubu, Jun</creatorcontrib><creatorcontrib>Yoshida, Jun</creatorcontrib><creatorcontrib>Kawamura, Izuru</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Hisako</au><au>Aisawa, Sumio</au><au>Ida, Honoka</au><au>Shimizu, Masaru</au><au>Watanabe, Keisuke</au><au>Koshoubu, Jun</au><au>Yoshida, Jun</au><au>Kawamura, Izuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two-dimensional Imaging of a Model Pharmaceutical Dosage Tablet Using a Scanning Vibrational Circular Dichroism System</atitle><jtitle>Chemistry letters</jtitle><date>2022-02-05</date><risdate>2022</risdate><volume>51</volume><issue>2</issue><spage>205</spage><epage>207</epage><pages>205-207</pages><issn>0366-7022</issn><eissn>1348-0715</eissn><abstract>A vibrational circular dichroism (VCD) system with a quantum-cascade laser was used to obtain a two-dimensional image of VCD signals on a pharmaceutical tablet. A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides as excipients. VCD spectra were obtained in the range 1500–1700 cm−1 at a 1 mm i.d. spatial resolution. The results demonstrated the utility of the proposed system in quality control during drug manufacturing.</abstract><cop>Tokyo</cop><pub>The Chemical Society of Japan</pub><doi>10.1246/cl.210635</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0366-7022 |
| ispartof | Chemistry letters, 2022-02, Vol.51 (2), p.205-207 |
| issn | 0366-7022 1348-0715 |
| language | eng |
| recordid | cdi_proquest_journals_2634877657 |
| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Dichroism Dosage Hydroxides Pharmaceuticals Phenylalanine Quality control Quantum cascade lasers Reagents Spatial resolution Tartaric acid Two dimensional models |
| title | Two-dimensional Imaging of a Model Pharmaceutical Dosage Tablet Using a Scanning Vibrational Circular Dichroism System |
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