Two-dimensional Imaging of a Model Pharmaceutical Dosage Tablet Using a Scanning Vibrational Circular Dichroism System

Two-dimensional Imaging of a Model Pharmaceutical Dosage Tablet Using a Scanning Vibrational Circular Dichroism System

A vibrational circular dichroism (VCD) system with a quantum-cascade laser was used to obtain a two-dimensional image of VCD signals on a pharmaceutical tablet. A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides...

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Veröffentlicht in:Chemistry letters 2022-02, Vol.51 (2), p.205-207
Hauptverfasser: Sato, Hisako, Aisawa, Sumio, Ida, Honoka, Shimizu, Masaru, Watanabe, Keisuke, Koshoubu, Jun, Yoshida, Jun, Kawamura, Izuru
Format: Artikel
Sprache:eng
Schlagworte:
Dichroism
Dosage
Hydroxides
Pharmaceuticals
Phenylalanine
Quality control
Quantum cascade lasers
Reagents
Spatial resolution
Tartaric acid
Two dimensional models
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Zusammenfassung:A vibrational circular dichroism (VCD) system with a quantum-cascade laser was used to obtain a two-dimensional image of VCD signals on a pharmaceutical tablet. A KBr disc of a model dosage form was prepared using tartaric acid and phenylalanine as chiral multi-reagents and layered double hydroxides as excipients. VCD spectra were obtained in the range 1500–1700 cm−1 at a 1 mm i.d. spatial resolution. The results demonstrated the utility of the proposed system in quality control during drug manufacturing.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.210635