Impaired neuromuscular transmission in facial muscles of amyotrophic lateral sclerosis: A single‐fiber electromyography study

Impaired neuromuscular transmission in facial muscles of amyotrophic lateral sclerosis: A single‐fiber electromyography study

Background Decremental responses in repetitive nerve stimulation studies have been reported in the limb muscles of patients with amyotrophic lateral sclerosis (ALS). Aim To reveal the function of neuromuscular junction (NMJ) in the frontalis muscle, which is less affected in ALS. Methods We performe...

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Veröffentlicht in:Neurology and clinical neuroscience 2022-03, Vol.10 (2), p.78-82
Hauptverfasser: Watanabe, Keisuke, Shibuya, Kazumoto, Misawa, Sonoko, Nagashima, Kengo, Suzuki, Yo‐ichi, Suichi, Tomoki, Kojima, Yuta, Nakamura, Keigo, Kano, Hiroki, Prado, Mario, Uzawa, Akiyuki, Kuwabara, Satoshi
Format: Artikel
Sprache:eng
Schlagworte:
Amyotrophic lateral sclerosis
Electromyography
facial muscles
Muscles
Myasthenia
Myasthenia gravis
Nerve endings
Neuromuscular junctions
neuromuscular transmission
single‐fiber electromyography
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Zusammenfassung:Background Decremental responses in repetitive nerve stimulation studies have been reported in the limb muscles of patients with amyotrophic lateral sclerosis (ALS). Aim To reveal the function of neuromuscular junction (NMJ) in the frontalis muscle, which is less affected in ALS. Methods We performed axonal‐stimulated single‐fiber EMG studies in the frontalis muscles in 27 patients with ALS, 32 with myasthenia gravis (MG), and 12 healthy controls were performed. Results The mean value of mean consecutive difference (MCD) in ALS was greater than controls (P 
ISSN:2049-4173
2049-4173
DOI:10.1111/ncn3.12580