Hip abductor weakness in anti‐signal recognition particle antibody‐positive myopathy
A 40‐year‐old man presented with a 3‐month history of progressive weakness of the four limbs. On examination, weakness of the hip abductor was marked. While walking, shoulder sway was noted as a compensation for hip abductor weakness. Blood tests showed a marked elevation of creatine kinase (CK) lev...
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| Veröffentlicht in: | Neurology and clinical neuroscience 2022-03, Vol.10 (2), p.102-104 |
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| creator | Yamada, Takayuki Kobayashi, Zen Inoue, Keisuke Tomimitsu, Hiroyuki |
| description | A 40‐year‐old man presented with a 3‐month history of progressive weakness of the four limbs. On examination, weakness of the hip abductor was marked. While walking, shoulder sway was noted as a compensation for hip abductor weakness. Blood tests showed a marked elevation of creatine kinase (CK) level and the presence of anti‐signal recognition particle (SRP) antibodies. Thigh muscle MRI demonstrated the presence of inflammation in various muscles including the gluteus medius. Clinicians should consider the possibility of anti‐SRP antibody‐positive myopathy in patients presenting with hip abductor weakness in a subacute onset. |
| doi_str_mv | 10.1111/ncn3.12578 |
| format | Article |
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On examination, weakness of the hip abductor was marked. While walking, shoulder sway was noted as a compensation for hip abductor weakness. Blood tests showed a marked elevation of creatine kinase (CK) level and the presence of anti‐signal recognition particle (SRP) antibodies. Thigh muscle MRI demonstrated the presence of inflammation in various muscles including the gluteus medius. Clinicians should consider the possibility of anti‐SRP antibody‐positive myopathy in patients presenting with hip abductor weakness in a subacute onset.</description><identifier>ISSN: 2049-4173</identifier><identifier>EISSN: 2049-4173</identifier><identifier>DOI: 10.1111/ncn3.12578</identifier><language>eng</language><publisher>Tokyo: Wiley Subscription Services, Inc</publisher><subject>anti‐signal recognition particle antibody‐positive myopathy ; Creatine ; Creatine kinase ; gluteus medius ; Hip ; hip abductor ; Magnetic resonance imaging ; Muscles ; Myopathy ; Signal recognition particle</subject><ispartof>Neurology and clinical neuroscience, 2022-03, Vol.10 (2), p.102-104</ispartof><rights>2022 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2478-7d7fd09854b90ae240d4ac21157980a7e476e3f15be8ddb8c88c2ecc463aa0ec3</cites><orcidid>0000-0003-4257-3029</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fncn3.12578$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fncn3.12578$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids></links><search><creatorcontrib>Yamada, Takayuki</creatorcontrib><creatorcontrib>Kobayashi, Zen</creatorcontrib><creatorcontrib>Inoue, Keisuke</creatorcontrib><creatorcontrib>Tomimitsu, Hiroyuki</creatorcontrib><title>Hip abductor weakness in anti‐signal recognition particle antibody‐positive myopathy</title><title>Neurology and clinical neuroscience</title><description>A 40‐year‐old man presented with a 3‐month history of progressive weakness of the four limbs. 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Clinicians should consider the possibility of anti‐SRP antibody‐positive myopathy in patients presenting with hip abductor weakness in a subacute onset.</description><subject>anti‐signal recognition particle antibody‐positive myopathy</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>gluteus medius</subject><subject>Hip</subject><subject>hip abductor</subject><subject>Magnetic resonance imaging</subject><subject>Muscles</subject><subject>Myopathy</subject><subject>Signal recognition particle</subject><issn>2049-4173</issn><issn>2049-4173</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kLFOwzAQhi0EEhV04QkisSGl2LFTOyOqgCJVZQGJzXKcS3FJ7WCnVNl4BJ6RJ8FtGJj4lzvpvjv99yN0QfCERF1bbemEZDkXR2iUYVakjHB6_Kc_ReMQ1jiqKCgpxAi9zE2bqLLa6s75ZAfqzUIIibGJsp35_vwKZmVVk3jQbmVNZ5xNWuU7oxs4IKWr-oi1LsThBySb3rWqe-3P0UmtmgDj33qGnu9un2bzdPF4_zC7WaQ6Y1ykvOJ1hQuRs7LACjKGK6Z0RkjOC4EVB8anQGuSlyCqqhRaCJ2B1mxKlcKg6Rm6HO623r1vIXRy7bY-Wg4ym1LGKY5_R-pqoLR3IXioZevNRvleEiz34cl9ePIQXoTJAO9MA_0_pFzOlnTY-QFuQXRp</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Yamada, Takayuki</creator><creator>Kobayashi, Zen</creator><creator>Inoue, Keisuke</creator><creator>Tomimitsu, Hiroyuki</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-4257-3029</orcidid></search><sort><creationdate>202203</creationdate><title>Hip abductor weakness in anti‐signal recognition particle antibody‐positive myopathy</title><author>Yamada, Takayuki ; Kobayashi, Zen ; Inoue, Keisuke ; Tomimitsu, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2478-7d7fd09854b90ae240d4ac21157980a7e476e3f15be8ddb8c88c2ecc463aa0ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>anti‐signal recognition particle antibody‐positive myopathy</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>gluteus medius</topic><topic>Hip</topic><topic>hip abductor</topic><topic>Magnetic resonance imaging</topic><topic>Muscles</topic><topic>Myopathy</topic><topic>Signal recognition particle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Takayuki</creatorcontrib><creatorcontrib>Kobayashi, Zen</creatorcontrib><creatorcontrib>Inoue, Keisuke</creatorcontrib><creatorcontrib>Tomimitsu, Hiroyuki</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Neurology and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Takayuki</au><au>Kobayashi, Zen</au><au>Inoue, Keisuke</au><au>Tomimitsu, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hip abductor weakness in anti‐signal recognition particle antibody‐positive myopathy</atitle><jtitle>Neurology and clinical neuroscience</jtitle><date>2022-03</date><risdate>2022</risdate><volume>10</volume><issue>2</issue><spage>102</spage><epage>104</epage><pages>102-104</pages><issn>2049-4173</issn><eissn>2049-4173</eissn><abstract>A 40‐year‐old man presented with a 3‐month history of progressive weakness of the four limbs. 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| language | eng |
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| subjects | anti‐signal recognition particle antibody‐positive myopathy Creatine Creatine kinase gluteus medius Hip hip abductor Magnetic resonance imaging Muscles Myopathy Signal recognition particle |
| title | Hip abductor weakness in anti‐signal recognition particle antibody‐positive myopathy |
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