Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to N -alkylated 2-pyridones

Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to N -alkylated 2-pyridones

A rhodium-catalyzed dearomative rearrangement reaction of 2-oxypyridines has been developed by using cyclopropenes as carbene precursors. This protocol features broad substrate scope and mild reaction conditions, providing a reliable and practical approach for the highly efficient synthesis of 2-alk...

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Veröffentlicht in:Organic Chemistry Frontiers 2022-03, Vol.9 (5), p.1295-1299
Hauptverfasser: Cui, Honglian, Xu, Guangyang, Zhu, Jie, Sun, Jiangtao
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Catalysis
Organic chemistry
Organic compounds
Rhodium
Substrates
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Zusammenfassung:A rhodium-catalyzed dearomative rearrangement reaction of 2-oxypyridines has been developed by using cyclopropenes as carbene precursors. This protocol features broad substrate scope and mild reaction conditions, providing a reliable and practical approach for the highly efficient synthesis of 2-alkylated 2-pyridone derivatives from readily available O -substituted pyridine compounds.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/D1QO01937F