Histologie Variants of Urothelial Carcinoma: A REtrospective Study of Cystoscopic Biopsies

All the specimens were fixed in 10% buffered formalin, paraffin sections and stained with Hematoxylin -Eosin stain.Histological analysis of the slides was carried out. The most common histologic variant of urothelial carcinoma (19.64%)was with squamous differentiation,followed byglandular differentiation (5.35%).Squamous differentiation was characterized by nests of malignant polygonal cells often showing keratinization with keratin pearl formation {Fig 2).Some of the areas of the tumor exhibited clear cell features (Fig 3).Glandular differentiation depicted true glandular spaces within urothelial carcinoma(Fig 4).Other variants of infiltrating urothelial carcinomas constituted a single case of sarcomatoid,plasmacytoid and nested type.Sarcomatoid variant showed biphasic malignant tumorfF? [13'15! A solitary case each of sarcomatoid,plasmacytoid and nested variant was present in our series.lt is important to recognize histological variants of urothelial carcinoma as they indicate aggressive disease.Diagnosis can pose challenges due to sampling limitations and inter observer variability. Conclusion Urothelial carcinoma is a common malignant tumor of urinary bladder.lt displays many variant morphologic appearances, which pose diagnostic challenge and have aggressive behavior.Recognition of divergent differentiation and variants of infiltrating urothelial carcinoma is essential because of implications for management and prognosis.