Synthesis of New Ursane-Type Hybrids with Morpholinomethyl-, Dialkylamino-, and Hydroxyl-Substituted Azoles
Ursane-type triterpenoids containing functionalized heterocyclic substituents were chemically modified. Aminomethylation of ursane hybrids with 1,3,4-oxadiazole- and 1,2,4-triazolethiones occurred smoothly to form new potentially biologically active derivatives of pentacyclic triterpenoids containin...
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Veröffentlicht in: | Chemistry of natural compounds 2022, Vol.58 (1), p.65-70 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Ursane-type triterpenoids containing functionalized heterocyclic substituents were chemically modified. Aminomethylation of ursane hybrids with 1,3,4-oxadiazole- and 1,2,4-triazolethiones occurred smoothly to form new potentially biologically active derivatives of pentacyclic triterpenoids containing 4-morphlinomethyl-5-thioxo-1,3,4-oxadiazole or 4-morpholinomethyl-5-thioxo-1,2,4-triazole substituents. Nucleophilic substitution of a methanesulfonyl group in a 1,3,4-oxadiazole substituent of a pentacyclic triterpenoid synthesized ursane-type hybrids with 2-hydroxyoxadiazoles and 2-dialkylaminooxadiazoles. |
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ISSN: | 0009-3130 1573-8388 |
DOI: | 10.1007/s10600-022-03597-x |