Cross‐Electrophile Coupling between Aryl/Vinyl Triflates and Vinyl Tosylates for the Synthesis of gem‐Difluoroalkenes via Ni/Pd Cooperative Catalysis

A dual nickel‐/palladium‐catalyzed direct gem‐difluorovinylation of readily available aryl/vinyl triflates with substituted gem‐difluorovinyl tosylates is presented. This protocol affords various diaryldifluoroalkene, arylalkyldifluoroalkene and 1,1‐difluoro‐2‐substituted‐1,3‐dienes under mild reaction conditions with excellent functional group compatibility, and provides a potential pathway to the late‐stage functionalization of complex bioactive molecules.