One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

One-step hydroxylation of aryl and heteroaryl fluorides using mechanochemistry

Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally frie...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2022-02, Vol.24 (4), p.1469-1473
Hauptverfasser: Rodrigo, Eduardo, Wiechert, Rainer, Walter, Magnus W, Braje, Wilfried, Geneste, Hervé
Format: Artikel
Sprache:eng
Schlagworte:
Fluorides
Green chemistry
Hydroxylation
Potassium
Potassium hydroxide
Potassium hydroxides
Substrates
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Zusammenfassung:Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation. Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions.
ISSN:1463-9262
1463-9270
DOI:10.1039/d1gc04361g