Preparation and validation of [67Ga]Ga-phytate kit and Monte Carlo dosimetry: an effort toward developing an impressive lymphoscintigraphy tracer

Preparation and validation of [67Ga]Ga-phytate kit and Monte Carlo dosimetry: an effort toward developing an impressive lymphoscintigraphy tracer

Radiocolloides are essential for the detection of metastatic lymph nodes in breast cancer. In this study [ 67 Ga]Ga-phytate, as an long-lived alternative for [ 99m Tc]Tc-radiocolloids was prepared. "Standard" labeling conditions for [ 67 Ga]Ga-phytate preparation (95–100 °C, 30 min, 0.5 mg...

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Veröffentlicht in:Journal of radioanalytical and nuclear chemistry 2022-02, Vol.331 (2), p.691-700
Hauptverfasser: Bayat, Zeinab, Saeedzadeh, Elham, Vahidfar, Nasim, Sadeghi, Mahdi, Farzenefar, Saeed, Daha, Fariba Johari, Salehi, Yalda
Format: Artikel
Sprache:eng
Schlagworte:
Aqueous solutions
Biomedical engineering
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Dosimeters
Dosimetry
Hadrons
Heavy Ions
Inorganic Chemistry
Medical colleges
Nuclear Chemistry
Nuclear Physics
Phosphates
Physical Chemistry
Phytic acid
Radiation
Radiochemistry
Tracers (Biology)
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Zusammenfassung:Radiocolloides are essential for the detection of metastatic lymph nodes in breast cancer. In this study [ 67 Ga]Ga-phytate, as an long-lived alternative for [ 99m Tc]Tc-radiocolloids was prepared. "Standard" labeling conditions for [ 67 Ga]Ga-phytate preparation (95–100 °C, 30 min, 0.5 mg phytic acid, aqueous solutions) has been adopted (radiochemical purity: > 98 ± 2% ITLC, specific activity: 0.9–1.1 GBq/mmol). The complex is mainly cleared from the blood pool through the liver by hepatic system (> 90%) and a small percentage (
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-021-08183-z