In vitro cytotoxicity and antibacterial activity of [Pd(AMTTO)(PPh 3 ) 2 ]: a novel promising palladium( ii ) complex

The synthesis of a new palladium( ii ) complex, [Pd(AMTTO)(PPh 3 ) 2 ] (1, H 2 AMTTO = 4-amino-6-methyl-1,2,4-triazine-3-thione-5-one), is reported. Complex 1 has been characterized by FT-IR, 1 H NMR and 31 P NMR spectroscopy as well as mass spectrometry. Furthermore, its molecular structure and thermal stability have been investigated via X-ray and thermogravimetric analyses. The crystal structure of 1 revealed that the twofold deprotonated ligand acts as a bidentate chelating one and coordinates to the metal ion through its sulfur and nitrogen atoms in a cis -arrangement. The biological activity including anticancer and antibacterial activity of the ligands and complex 1 was studied. The IC 50 value of the latter against MCF-7 was 0.06 mM. This is while carboplatin (as a standard anticancer drug) exhibited no cytotoxicity at the same concentration. Moreover, the synthesized Pd( ii ) complex displayed potent antimicrobial activity against Gram-positive ( ATCC 6538 ) and Gram-negative ( ATCC 25922 ) bacterial strains.