Characteristics of unintentional ingestion of oral nonsteroidal anti-inflammatory drugs and analgesics in preschool children

According to the last 2019 report issued by the Croatian Agency for Medicinal Products and Medical Devices (HALMED), consumption of antiinflammatory drugs had increased 8 % a year in average between 2015 and 2019 (1). METHODS Data selection and extraction Our retrospective analysis included anonymised data from two sources: records from telephone consultations with the CPCC and hospital records of cases treated at the Department for Paediatric Clinical Pharmacology and Toxicology of the Children's Hospital Zagreb (CHZ). To calculate ingested doses in mg/ kg in cases without reported body weight [89 of 340 CPCC cases with a reported dose and 31 of 47 CHZ cases with reported dose], we took median body weight for reported age and sex from the World Health Organization's Child Growth Standards (8). [...]only minor gastrointestinal symptoms (vomiting, diarrhoea) and some laboratory abnormalities were noted with paracetamol (Table 2), but no elevated serum liver enzymes or liver function abnormalities.